Investigating the Pathogen Genomic Determinants of Tuberculosis Transmission

In this issue of the Journal, the article by Nebenzahl-Guimaraes and colleagues (pp. 1519–1527) is a novel look at the whole-genome determinants of Mycobacterium tuberculosis transmission (1). Relative to many other bacterial species, M. tuberculosis has comparatively little sequence diversity (2). This lack of diversity has limited findings from genotype–phenotype association studies that have used low resolution genotyping techniques